Affiliation:
1. State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210023, China
Abstract
Isoliquiritigenin (2’,4’,4-trihydroxychalcone, ISL) is one of the most important
chalcone compounds which is mainly derived from licorice root and many other plants. It exhibits
a remarkable range of potent biological and pharmacological activities such as antioxidative,
antitumor, antiaging, anti-inflammatory, anti-diabetic activities, etc. Numerous research
teams have demonstrated that ISL posseses the ability to carry out antigrowth and proliferation
in various cancer cells in vitro and in vivo. Meanwhile, the underlying mechanisms
of ISL that inhibit cancer cell proliferation have not been well explored. However, the poor
bioavailability and low water-soluble limit its clinical application. This review aims at providing
a comprehensive overview of the pharmacology antitumor activity of ISL and its mechanisms
in different malignancy especially in breast cancer cell line and summarize developments
of formulation utilized to overcome the barrier between its delivery characteristics and
application in clinics over the past 20 years.
Funder
National Natural Science Foundation of China
Publisher
Bentham Science Publishers Ltd.
Subject
Pharmacology,Molecular Medicine,Drug Discovery,Biochemistry,Organic Chemistry
Reference71 articles.
1. Peng F.; Du Q.; Peng C.; Wang N.; Tang H.; Xie X.; Shen J.; Chen J.A.; Review: The pharmacology of isoliquiritigenin. Phytother Res 2015,29(7),969-977
2. Kwon H.M.; Choi Y.J.; Choi J.S.; Kang S.W.; Bae J.Y.; Kang I.J.; Jun J.G.; Lee S.S.; Lim S.S.; Kang Y.H.; Blockade of cytokine-induced endothelial cell adhesion molecule expression by licorice isoliquiritigenin through NF-kappaB signal disruption. Exp Biol Med (Maywood) 2007,232(2),235-245
3. Chen Y.P.; Zhang Z.Y.; Li Y.P.; Li D.; Huang S.L.; Gu L.Q.; Xu J.; Huang Z.S.; Syntheses and evaluation of novel isoliquiritigenin derivatives as potential dual inhibitors for amyloid-beta aggregation and 5-lipoxygenase. Eur J Med Chem 2013,66,22-31
4. Gaur R.; Thakur J.P.; Yadav D.K.; Kapkoti D.S.; Verma R.K.; Gupta N.; Khan F.; Saikia D.; Bhakuni, R.S.; Erratum to: Synthesis, antitubercular activity, and molecular modeling studies of analogues of isoliquiritigenin and liquiritigenin, bioactive components from Glycyrrhiza glabra. Med Chem Res 2015,24,3772-3774
5. Iwata S.; Nagata N.; Omae A.; Yamaguchi S.; Okada Y.; Shibata S.; Okuyama T.; Inhibitory effect of chalcone derivatives on recombinant human aldose reductase. Biol Pharm Bull 1999,22(3),323-325
Cited by
35 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献