Anti-gout and urate-lowering potentials of curcumin: A review from bench to beside

Author:

Jafari-Nozad Amir Masoud1,Jafari Amirsajad2,Yousefi Saman3,Bakhshi Hasan4,Farkhondeh Tahereh56,Samarghandian Saeed7

Affiliation:

1. Student Research Committee, Birjand University of Medical Sciences, Birjand, Iran

2. Faculty of Veterinary Medicine, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran

3. Islamic Azad University of Shahrekord School of Veterinary Medicine, Shahr-e Kord Iran

4. Vector-borne Diseases Research Center, North Khorasan University of Medical Sciences, Bojnurd, Iran

5. Department of Toxicology and Pharmacology, School of Pharmacy, Birjand University of Medical Sciences, Birjand, Iran.

6. Healthy Ageing Research Centre, Neyshabur University of Medical Sciences, Neyshabur 9318614139, Iran

7. Healthy Ageing Research Centre, Neyshabur University of Medical Sciences, Neyshabur , Iran

Abstract

Background: Gouty arthritis is a complex form of inflammatory arthritis, triggered by the sedimentation of monosodium urate crystals in periarticular tissues, synovial joints, and other sites in the body. Curcumin is a natural polyphenol compound, isolated from the rhizome of the plant Curcuma longa, possessing countless physiological features, including antioxidant, anti-inflammatory, and anti-rheumatic qualities. Objective: This study aimed to discuss the beneficial impacts of curcumin and its mechanism in treating gout disease. Methods: Ten English and Persian databases were used to conduct a thorough literature search. Studies examining the anti-gouty arthritis effects of curcumin and meeting the inclusion criteria were included. Results: According to the studies, curcumin has shown xanthine oxidase and urate transporter-1 inhibitory properties, uric acid inhibitory characteristics, and antioxidant and anti-inflammatory effects. However, some articles found no prominent reduction in uric acid levels. Conclusion: In this review, we emphasized the potency of curcumin and its compounds against gouty arthritis. Despite the potency, we suggest an additional well-designed evaluation of curcumin, before its therapeutic effectiveness is completely approved as an anti-gouty arthritis agent.

Publisher

Bentham Science Publishers Ltd.

Subject

Pharmacology,Molecular Medicine,Drug Discovery,Biochemistry,Organic Chemistry

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