Affiliation:
1. Department of Environmental Analysis, Faculty of Chemistry, University of Gdansk, Poland
2. Department of Pharmaceutical Biochemistry, Medical University of Gdansk, Gdansk, Poland
Abstract
Background:
Obesity, insulin resistance, diabetes, and metabolic syndrome are associated
with lipid alterations, and they affect the risk of long-term cardiovascular disease. A reliable
analytical instrument to detect changes in the composition or structures of lipids and the
tools allowing to connect changes in a specific group of lipids with a specific disease and its progress,
is constantly lacking. Lipidomics is a new field of medicine based on the research and
identification of lipids and lipid metabolites present in human organism. The primary aim of lipidomics
is to search for new biomarkers of different diseases, mainly civilization diseases.
Objective:
We aimed to review studies reporting the application of mass spectrometry for lipid
analysis in metabolic diseases.
Method:
Following an extensive search of peer-reviewed articles on the mass spectrometry
analysis of lipids the literature has been discussed in this review article.
Results:
The lipid group contains around 1.7 million species; they are totally different, in terms
of the length of aliphatic chain, amount of rings, additional functional groups. Some of them are
so complex that their complex analyses are a challenge for analysts. Their qualitative and quantitative
analysis of is based mainly on mass spectrometry.
Conclusion:
Mass spectrometry techniques are excellent tools for lipid profiling in complex biological
samples and the combination with multivariate statistical analysis enables the identification
of potential diagnostic biomarkers.
Funder
University of Gdansk
Medical University of Gdansk
Publisher
Bentham Science Publishers Ltd.
Subject
Pharmacology,Molecular Medicine,Drug Discovery,Biochemistry,Organic Chemistry
Cited by
14 articles.
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