The Predictive Role for ST2 in Patients with Acute Coronary Syndromes and Heart Failure

Author:

Tsigkou Vasiliki1,Siasos Gerasimos1,Bletsa Evanthia1,Panoilia Maria-Evi1,Papastavrou Angeliki1,Kokosias Georgios1,Oikonomou Evangelos1,Papageorgiou Nikolaos1,Zaromitidou Marina1,Marinos Georgios1,Vavuranakis Manolis1,Stefanadis Christodoulos2,Papavassiliou Athanasios G.3,Tousoulis Dimitris1

Affiliation:

1. Department of Cardiology, Hippokration General Hospital, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece

2. MYSM School of Medicine, Yale University, New Haven, CT, United States

3. Department of Biological Chemistry, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece

Abstract

Intensive research has shed light on the utilization of novel biomarkers which facilitate the diagnosis and prognosis of patients with different medical problems. One of the most important biomarkers especially in the spectrum of heart failure is soluble ST2 (sST2: soluble Suppression of Tumorigenicity 2), which is involved in inflammation, fibrosis and cardiac stress. In the revised 2017 ACC/AHA/HFSA, “Focused Update Guidelines for the Management of Heart Failure” ST2 was given a class-IIa recommendation for the optimal risk assessment in patients with heart failure. Many studies indicate that not only baseline but also serial measurements of ST2 can accurately predict future cardiovascular events in patients with Acute Coronary Syndromes and heart failure. Therefore, in this review, we are going to discuss the studies about the prognostic significance of ST2 in patients with Acute Coronary Syndromes, acute and chronic heart failure.

Publisher

Bentham Science Publishers Ltd.

Subject

Pharmacology,Molecular Medicine,Drug Discovery,Biochemistry,Organic Chemistry

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