3D Culture Modelling: An Emerging Approach for Translational Cancer Research in Sarcomas-Reference-Cited by-同舟云学术

3D Culture Modelling: An Emerging Approach for Translational Cancer Research in Sarcomas

Published:2020-09-02 Issue:29 Volume:27 Page:4778-4788
ISSN:0929-8673
Container-title:Current Medicinal Chemistry
language:en
Short-container-title:CMC

Author:

Heredia-Soto Victoria¹,Redondo Andrés¹,Kreilinger José Juan Pozo²,Martínez-Marín Virginia¹,Berjón Alberto²,Mendiola Marta²

Affiliation:

1. Translational Oncology Group, IdiPAZ, La Paz University Hospital, Madrid, Spain

2. Molecular Pathology and Therapeutic Targets Group, Idi- PAZ,La Paz University Hospital, Madrid, Spain

Abstract

Sarcomas are tumours of mesenchymal origin, which can arise in bone or soft tissues. They are rare but frequently quite aggressive and with a poor outcome. New approaches are needed to characterise these tumours and their resistance mechanisms to current therapies, responsible for tumour recurrence and treatment failure. This review is focused on the potential of three-dimensional (3D) in vitro models, including multicellular tumour spheroids (MCTS) and organoids, and the latest data about their utility for the study on important properties for tumour development. The use of spheroids as a particularly valuable alternative for compound high throughput screening (HTS) in different areas of cancer biology is also discussed, which enables the identification of new therapeutic opportunities in commonly resistant tumours.

Publisher

Bentham Science Publishers Ltd.

Subject

Pharmacology,Molecular Medicine,Drug Discovery,Biochemistry,Organic Chemistry

Reference55 articles.

1. Taylor B.S.; Barretina J.; Maki R.G.; Antonescu C.R.; Singer S.; Ladanyi M.; Advances in sarcoma genomics and new therapeutic targets. Nat Rev Cancer 2011,11(8),541-557

2. Doyle L.A.; Sarcoma classification: an update based on the 2013 World Health Organization Classification of tumors of soft tissue and bone. Cancer 2014,120(12),1763-1774

3. Nielsen T.O.; West R.B.; Translating gene expression into clinical care: sarcomas as a paradigm. J Clin Oncol 2010,28(10),1796-1805

4. Fletcher C.D.; The evolving classification of soft tissue tumours - an update based on the new 2013 WHO classification. Histopathology 2014,64(1),2-11

5. Sugita S.; Arai Y.; Tonooka A.; Hama N.; Totoki Y.; Fujii T.; Aoyama T.; Asanuma H.; Tsukahara T.; Kaya M.; Shibata T.; Hasegawa T.; A novel CIC-FOXO4 gene fusion in undifferentiated small round cell sarcoma: a genetically distinct variant of Ewing-like sarcoma. Am J Surg Pathol 2014,38(11),1571-1576

Cited by 6 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Evolution of the Solid Human Tumor Cells Properties in Various Experimental Systems in Vitro;Journal of Hematology and Oncology Research;2022-01-19

2. Eribulin activity in soft tissue sarcoma monolayer and three-dimensional cell line models: could the combination with other drugs improve its antitumoral effect?;Cancer Cell International;2021-12

3. The mystery behind the nostrils – technical clues for successful nasal epithelial cell cultivation;Annals of Anatomy - Anatomischer Anzeiger;2021-11

4. Induction of Apoptosis by Isoalantolactone in Human Hepatocellular Carcinoma Hep3B Cells through Activation of the ROS-Dependent JNK Signaling Pathway;Pharmaceutics;2021-10-06

5. Recapitulating Tumorigenesis in vitro: Opportunities and Challenges of 3D Bioprinting;Frontiers in Bioengineering and Biotechnology;2021-06-22