Role of Exosomes in Photodynamic Anticancer Therapy-Reference-Cited by-同舟云学术

Role of Exosomes in Photodynamic Anticancer Therapy

Published:2020-11-26 Issue:40 Volume:27 Page:6815-6824
ISSN:0929-8673
Container-title:Current Medicinal Chemistry
language:en
Short-container-title:CMC

Author:

Jiang Yuan¹^ORCID,Xu Chuanshan¹^ORCID,Leung Wingnang²^ORCID,Lin Mei¹^ORCID,Cai Xiaowen¹^ORCID,Guo Huanhuan¹^ORCID,Zhang Jiyong³^ORCID,Yang Fanwen⁴^ORCID

Affiliation:

1. Key Laboratory of Molecular Target and Clinical Pharmacology, State Key Laboratory of Respiratory Disease, School of Pharmaceutical Science & Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong 511436, China

2. Division of Chinese Medicine, School of Professional and Continuing Education, The University of Hong Kong, Hong Kong

3. Shenzhen Maternity and Child Health Care Hospital, Shenzhen 518017, China

4. Department of Biomedical Engineering, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, Guangdong 511436, China

Abstract

Photodynamic Therapy (PDT) is a promising alternative treatment for malignancies based on photochemical reaction induced by Photosensitizers (PS) under light irradiation. Recent studies show that PDT caused the abundant release of exosomes from tumor tissues. It is well-known that exosomes as carriers play an important role in cell-cell communication through transporting many kinds of bioactive molecules (e.g. lipids, proteins, mRNA, miRNA and lncRNA). Therefore, to explore the role of exosomes in photodynamic anticancer therapy has been attracting significant attention. In the present paper, we will briefly introduce the basic principle of PDT and exosomes, and focus on discussing the role of exosomes in photodynamic anticancer therapy, to further enrich and boost the development of PDT.

Funder

Guangzhou Medical University

Guangdong Science and Technology Department

Education Department of Sichuan Province

Publisher

Bentham Science Publishers Ltd.

Subject

Pharmacology,Molecular Medicine,Drug Discovery,Biochemistry,Organic Chemistry

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