Affiliation:
1. The Mary and Garry Weston Molecular Immunology Laboratory, Thrombosis Research Institute, London SW3 6LR, England, United Kingdom
Abstract
Background:
Angiopoietin-Like Proteins (ANGPTLs) are structurally related to the
angiopoietins. A total of eight ANGPTLs (from ANGPTL1 to ANGPTL8) have been identified so
far. Most ANGPTLs possess multibiological functions on lipid metabolism, atherosclerosis, and
cancer. Among them, ANGPTL3 has been shown to regulate the levels of Very Low-Density
Lipoprotein (VLDL) made by the liver and play a crucial role in human lipoprotein metabolism.
Method:
A systematic appraisal of ANGPTLs was conducted, focusing on the main features of
ANGPTL3 that has a significant role in atherosclerosis.
Results:
Angiopoietins including ANGPTL3 are vascular growth factors that are highly specific for
endothelial cells, perform a variety of other regulatory activities to influence inflammation, and have
been shown to possess both pro-atherosclerotic and atheroprotective effects.
Conclusion:
ANGPTL3 has been demonstrated as a promising target in the pharmacological management
of atherosclerosis. However, many questions remain about its biological functions.
Publisher
Bentham Science Publishers Ltd.
Subject
Pharmacology,Molecular Medicine,Drug Discovery,Biochemistry,Organic Chemistry
Cited by
15 articles.
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