Affiliation:
1. Tianjin Medical University Eye Hospital, Tianjin Medical University Eye Institute, College of Optometry and Ophthalmology, Tianjin Medical University, Tianjin, 300384, China
Abstract
The ocular surface structure and extraocular accessory organs constitute the ocular surface
system, which includes the cornea, conjunctiva, eyelids, lacrimal organs, and lacrimal passages.
This system is composed of, and stabilized by, the corneal epithelium, conjunctival cells, conjunctival
goblet cells, lacrimal acinar cells and Tenon’s fibroblasts, all of which maintain the healthy eyeball
surface system. Ocular surface diseases are commonly referred to corneal and conjunctival disease
and external ocular disease, resulting from damage to the ocular surface structure. A growing
body of evidence has indicated that abnormal activation of the KCa3.1 channel and Ca2+/
calmodulin-dependent kinase initiates ocular injury. Signaling pathways downstream of the irregular
Ca2+ influx induce cell progression and migration, and impair tight junctions, epithelial transport and
secretory function. In this overview, we summarize the current knowledge regarding ocular surface
disease in terms of physical and pathological alteration of the ocular system. We dissect in-depth,
the mechanisms underlying disease progression, and we describe the current calcium transport
therapeutics and the obstacles that remain to be solved. Finally, we summarize how to integrate the
research results into clinical practice in the future.
Funder
National Natural Science Foundation of China
Publisher
Bentham Science Publishers Ltd.
Subject
Pharmacology,Molecular Medicine,Drug Discovery,Biochemistry,Organic Chemistry
Cited by
2 articles.
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