Recent Development on Anti-Obesity Compounds and their Mechanisms of Action: A Review

Author:

Qiu Yixing1,Yu Huanghe1,Zeng Rong1,Guo Shiyin2,Daniyal Muhammad1,Deng Zeyu1,Wang Aibing3,Wang Wei1

Affiliation:

1. TCM and Ethnomedicine Innovation & Development International Laboratory, Innovative Drug Research Institute, School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China

2. College of Food Science and Technology, Hunan Agricultural University, Changsha 410128, Hunan, China

3. The Key Laboratory of Animal Vaccine & Protein Engineering, College of Veterinary Medicine, Hunan Agricultural University, Changsha 410128, Hunan, China

Abstract

Obesity, associated with a series of complications such as diabetes, hypertension, and heart disease, is a great threat to human health and leads to increased morbidity and mortality. Despite the presence of anti-obesity agents on the market, the application of these drugs is limited because of their typical side effects. More effective and safe weight-loss drugs are being pursued by many researchers, correspondingly, growing small molecules and natural products with anti-obesity effects have been identified and the molecular mechanisms underlying the action of the novel and known compounds have at least partially been revealed. Therefore, the field does witness great progress year by year. In this review, we intend to provide a comprehensive and updated view on the known and novel compounds which possess anti-obesity effects and further classify them according to the molecular mechanisms of their actions in regulating the major anti-obesity pathways.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Hunan province, China

Research Foundation of Education Bureau of Hunan Province, China

Publisher

Bentham Science Publishers Ltd.

Subject

Pharmacology,Molecular Medicine,Drug Discovery,Biochemistry,Organic Chemistry

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