Affiliation:
1. Cancer Biology Lab, Department of Biochemistry and Bioinformatics, Institute of Science, GITAM (Deemed to be University), Visakhapatnam, 530045, India
2. King Fahd Medical Research Center, King Abdulaziz University, P. O. Box 80216, Jeddah 21589, Saudi Arabia
Abstract
The breast tumor microenvironment (TME) promotes drug resistance through
an elaborated interaction of TME components mediated by reactive oxygen species
(ROS). Although there is massive accumulation of data concerning the targeting of the
ROS, little is known about the ROS-responsive nanomedicine for targeting breast TME.
This review submits the ROS landscape in breast TME, including ROS biology, ROS mediated
carcinogenesis, and reprogramming of stromal and immune cells of TME. We also
discussed ROS-based precision strategies for imaging TME, including molecular imaging
techniques with advanced probes, multiplexed methods, and multi-omic profiling
strategies. ROS-responsive nanomedicine also describes various therapies, such as chemo-
dynamic, photodynamic, photothermal, sono-dynamic, immune, and gene therapy for
BC. We expound ROS-responsive primary delivery systems for chemotherapeutics, phytochemicals,
and immunotherapeutics. This review also presents recent updates on nanotheranostics
for simultaneous diagnosis and treatment of BCs. We assume that a review
on this advancing field will be beneficial to the development of ROS-based nano-theranostics
for BC.
Funder
Ministry of Science and technology, EMR, India
Publisher
Bentham Science Publishers Ltd.
Subject
Pharmacology,Molecular Medicine,Drug Discovery,Biochemistry,Organic Chemistry
Cited by
7 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献