Biomarkers In Hypertension And Hypertension-Related Disorders

Author:

Resende Rodrigo R.1,de Carvalho Ribeiro Patrícia2,Oliveira Lucas Felipe34,Filho Daniel Mendes5,Parreira Ricardo Cambraia6,Vieira Mariana Sousa1,Marques Bruno Lemes7,da Madeira Freitas Elis Marra7,Silva Walison N.8,Santiago Helton da Costa9,Birbrair Alexander10,Ulrich Henning411,da Silva Valdo José Dias124

Affiliation:

1. Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.

2. Department of Oncology, Georgetown University, Washington, DC, United States

3. Department of Physiology, Biological and Natural Sciences Institute, Triangulo Mineiro Federal University, Uberaba, MG, Brazil

4. National Institute of Science and Technology for Regenerative Medicine, Rio de Janeiro, RJ, Brazil

5. Department of Physiology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil.

6. University Centre of Mineiros (UNIFIMES), Trindade, GO, Brazil

7. Laboratory of Neuropharmacology and Neurochemistry, Institute of Biological Sciences, Federal University of Goiás, Goiânia, GO, Brazil

8. Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, Brazil.

9. Department of Biochemistry and Immunology, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.

10. Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil

11. Department of Biochemistry, Institute of Chemistry, University of Sao Paulo, Sao Paulo, Brazil

12. Department of Physiology, Biological and Natural Sciences Institute, Triangulo Mineiro Federal University, Uberaba, MG, Brazil.

Abstract

Abstract: Systemic arterial hypertension (SAH) is a major risk factor for several secondary diseases, especially those involving cardiovascular and renal conditions. SAH has a high prevalence worldwide and its precise and early recognition is important to prevent the development of secondary outcomes. In this field, the study of biomarkers represents an important approach to diagnose and predict the disease and its associated conditions. The use of biomarkers in hypertension and hypertension-related disorders, such as ischemic stroke, intracerebral hemorrhage, transient ischemic attack, acute myocardial infarction, angina pectoris and chronic kidney disease, are discussed in this review. Establishing a potential pool of biomarkers may contribute to a non-invasive and improved approach for their diagnosis, prognosis, risk assessment, therapy management and pharmacological responses to a therapeutic intervention, in order to improve quality of life in patients and prevent unfavorable outcomes.

Publisher

Bentham Science Publishers Ltd.

Subject

Pharmacology,Molecular Medicine,Drug Discovery,Biochemistry,Organic Chemistry

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