Potential Role of SUMO and SUMOylation in the Pathogenesis of Diabetes Mellitus-Reference-Cited by-同舟云学术

Potential Role of SUMO and SUMOylation in the Pathogenesis of Diabetes Mellitus

Published:2023-04 Issue:14 Volume:30 Page:1623-1637
ISSN:0929-8673
Container-title:Current Medicinal Chemistry
language:en
Short-container-title:CMC

Author:

Sahebkar Amirhossein¹²³⁴,Sadeghi Mahvash⁵⁶,Dehnavi Sajad⁷⁶,Shohan Mojtaba⁵⁶,Jamialahmadi Tannaz¹⁸,Sathyapalan Thozhukat⁹

Affiliation:

1. Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

2. Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran

3. School of Medicine, The University of Western Australia, Perth, Australia

4. Department of Biotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

5. Department of Immunology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

6. Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

7. Department of Immunology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

8. Surgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

9. Department of Academic Diabetes, Endocrinology and Metabolism, Hull York Medical School, University of Hull, Hull HU3 2JZ, UK

Abstract

Abstract: Diabetes mellitus is a group of metabolic disorders characterized by hyperglycemia and associated with multiple organ systems complications. The incidence and prevalence of diabetes are increasing in an epidemic proportion worldwide. In addition to environmental factors, some epigenetic and post-translational modifications have critical roles in the pathogenesis of diabetes and its complications. Reversible covalent modification such as SUMOylation by SUMO (Small Ubiquitin-like Modifier) has emerged as a new mechanism that affects the dynamic regulation of proteins. In this review, we initially focus on the function of SUMO and SUMOylation. Subsequently, we assess the potential effects of this process in the pathogenesis of type 1 and 2 diabetes mellitus.

Publisher

Bentham Science Publishers Ltd.

Subject

Pharmacology,Molecular Medicine,Drug Discovery,Biochemistry,Organic Chemistry

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