Affiliation:
1. Department of Radiobiology and Molecular Genetics, VINČA Institute of Nuclear Sciences, National Institute
of the Republic of Serbia, University of Belgrade, Belgrade, Serbia
Abstract
Abstract:
Metabolic diseases such as obesity, diabetes, dyslipidemia, and insulin resistance
are characterized by glucose and lipid metabolism alterations and represent a global
health problem. Many studies have established the crucial role of micro-ribonucleic
acids (miRNAs) in controlling metabolic processes in various tissues. miRNAs are single-
stranded, highly conserved non-coding RNAs containing 20-24 oligonucleotides that
are expressed in a tissue-specific manner. miRNAs mainly interact through base pairing
with 3' untranslated regions of target gene mRNAs to promote inhibition of their translation.
miRNAs regulate the expression of as many as 30% of the human genes and have a
role in crucial physiological processes such as human growth and development, cell proliferation,
apoptosis, and metabolism. The number of miRNA molecules with a confirmed
role in the pathogenesis of metabolic diseases is quickly expanding due to the
availability of high-throughput methodologies for their identification. In this review, we
present recent findings regarding the role of miRNAs as endocrine signaling molecules
involved in the regulation of insulin production and fat metabolism. We discuss the potential
of extracellular miRNAs present in biological fluids miRNAs as biomarkers for the
prediction of diabetes and MetS. We also give an updated overview of therapeutic interventions
based on antisense oligonucleotides and the CRISPR/Cas9 editing platform for
manipulating levels of miRNAs involved in metabolic disorders.
Funder
Ministry of Education, Science and Technological Development of the Republic of Serbia
Publisher
Bentham Science Publishers Ltd.
Subject
Pharmacology,Molecular Medicine,Drug Discovery,Biochemistry,Organic Chemistry
Cited by
10 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献