Utility of Fibrinogen Levels for Predicting Survival and Functional Outcomes in Patients with Acute Ischemic Stroke: A Meta-Analysis-Reference-Cited by-同舟云学术

Utility of Fibrinogen Levels for Predicting Survival and Functional Outcomes in Patients with Acute Ischemic Stroke: A Meta-Analysis

Published:2023-02 Issue:4 Volume:30 Page:481-491
ISSN:0929-8673
Container-title:Current Medicinal Chemistry
language:en
Short-container-title:CMC

Author:

Gong Dandan¹,Fan Yu¹,Xu Juan²,Sun Yimeng¹

Affiliation:

1. Institute of Molecular Biology & Translational Medicine, The Affiliated People’s Hospital, Jiangsu University, Zhenjiang, Jiangsu, 212002 China

2. Department of Oncology, Ganyu District People's Hospital of Lianyungang City, Jiangsu, 222100 China

Abstract

Background and Objective: Studies on the association between blood fibrinogen level and adverse outcomes in patients with acute ischemic stroke have produced controversial results. This meta-analysis aimed to examine the association of elevated fibrinogen level with adverse outcomes in acute ischemic stroke patients. Methods: Two authors comprehensively searched the articles indexed in PubMed and Embase databases until December 31, 2021. All cohort studies that assessed the value of fibrinogen level in predicting poor functional outcome or all-cause mortality in acute ischemic stroke patients were included. Results: Nine studies reporting on ten articles involving 16,998 patients met the inclusion criteria. For the highest versus lowest fibrinogen group, the pooled adjusted risk ratio (RR) was 1.48 (95% confidence intervals [CI] 1.17–1.87) for poor functional outcome defined by the modified Rankin Scale ≥ 3. In addition, elevated fibrinogen was not significantly associated with an increased risk of all-cause mortality (RR 1.76; 95% CI 1.42–2.20). Subgroup analysis suggested that there was no clear association between elevated fibrinogen level and PFO in younger acute ischemic stroke patients (RR 1.16; 95% CI 0.87–1.53). Conclusion: Elevated fibrinogen level at baseline is possibly an independent predictor of short-term poor functional outcome and long-term all-cause mortality, particularly in elderly acute ischemic stroke patients. Blood fibrinogen level may serve as a useful biomarker for risk classification of acute ischemic stroke patients.

Funder

Suqian Science and Technology Support Project Fund

Jiangsu 333 Talent Fund

Zhenjiang Key Research and Development Fund

Publisher

Bentham Science Publishers Ltd.

Subject

Pharmacology,Molecular Medicine,Drug Discovery,Biochemistry,Organic Chemistry

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