Affiliation:
1. College of Pharmaceutical Science, Zhejiang University of Technology and Institute of Drug Development
& Chemical Biology, Zhejiang University of Technology, Hangzhou 310014, P. R. China
Abstract
Abstract:
The sartans are a new class of antihypertensive drugs as angiotensin II receptor
blockers which possess plenty of advantages in treating hypertension and related
pathologies. This review describes the clinical treatment, side effects, and potential therapeutic
effects of sartans from 1995 to date. The synthesis, structural-activity and molecular
docking with Angiotensin Type 1 receptor of imidazole derivatives, benzimidazole
derivatives and other compounds are also described. With a clear Structure-Activity Relationship
and abundant pharmacological effects, some types of novel Angiotensin Type 1
receptor antagonists are emerging gradually for further research in the meantime.
Publisher
Bentham Science Publishers Ltd.
Subject
Pharmacology,Molecular Medicine,Drug Discovery,Biochemistry,Organic Chemistry
Cited by
2 articles.
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