Affiliation:
1. Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599, Singapore
Abstract
Breast cancer is one of the most lethal cancers in women worldwide, and the
development of efficient treatments faces several challenges. Breast cancer is characterized
by histological and functional heterogeneity in aspects such as tumorigenesis, metastasis,
and drug resistance. RNA therapy has emerged as a highly attractive class of drugs
for the treatment and prevention of breast cancer. It might play remarkable regulatory
roles in the treatment of targeted cells by either increasing or silencing expressions of specific
proteins, and such features of RNA-based drugs cause high selectivity and low risk
of off-target effect in breast cancer. RNA therapy exerts anti-proliferative and pro-apoptotic
effects upon cell culture systems, animal models, and in clinical trials in most
studies. In this mini-review, we outline the classifications, mechanisms, advantages, and
challenges of RNA therapy and highlight its application in breast cancer treatment. Additionally,
we summarize the clinical trials of RNA-targeting therapies and the development
of anti-tumor RNA drugs and provide future directions for RNA therapeutics in
breast cancer.
Funder
Singapore Ministry of Education’s Tier 3 Grants
NMRC Clinician Scientist-Individual Research Grant
Singapore Ministry of Education’s Tier 2 Grants
Publisher
Bentham Science Publishers Ltd.
Subject
Pharmacology,Molecular Medicine,Drug Discovery,Biochemistry,Organic Chemistry
Cited by
5 articles.
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