Is Curcumin a Safe and Effective Therapeutic in the Treatment against Oral Lichen Planus?-Reference-Cited by-同舟云学术

Is Curcumin a Safe and Effective Therapeutic in the Treatment against Oral Lichen Planus?

Published:2023-05 Issue:15 Volume:30 Page:1684-1688
ISSN:0929-8673
Container-title:Current Medicinal Chemistry
language:en
Short-container-title:CMC

Author:

Sahebkar Amirhossein¹²³⁴,Khosrojerdi Motahareh⁵,Gumpricht Eric⁶,Jamialahmadi Tannaz¹⁷,Kesharwani Prashant⁸

Affiliation:

1. Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

2. Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran

3. School of Medicine, The University of Western Australia, Perth, Australia

4. Department of Biotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

5. Department of Dentistry, Faculty of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran

6. Department of Pharmacology, Isagenix International, LLC, Gilbert, Arizona, AZ, 85297, USA

7. Surgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

8. Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi 110062, India

Abstract

Abstract: Oral lichen planus (OLP) is a chronic mucocutaneous, immunological disease that occurs more frequently in the buccal mucosa of middle-aged female patients. OLP's standard treatment is topical or systemic corticosteroids. Due to corticosteroids’ numerous potential side effects, there is an effort to find an alternative treatment. One alternative treatment is curcumin. Several studies have investigated the effectiveness and safety of curcumin in OLP patients. In this review, we summarized the literature focusing on the effectiveness and safety of curcumin in OLP patients. Our review of clinical trials revealed that either 6000 mg/day curcumin, 80 mg/day nano-curcumin, or 1% curcumin oral gel 6 times/day offered benefits in the treatment of OLP.

Publisher

Bentham Science Publishers Ltd.

Subject

Pharmacology,Molecular Medicine,Drug Discovery,Biochemistry,Organic Chemistry

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