Affiliation:
1. Departamento de Neurofisiología, Instituto Nacional de Neurología y Neurocirugía, México M.V.S. Insurgentes
Sur 3877, C.P. 14269, México
Abstract
Objective:
The purpose of this article is to describe the state-of-art of neuroanatomical
and cellular aspects of the cerebellum in epilepsy.
Background:
Over the years, cerebellum epileptogenesis has been widely studied. There
is growing evidence linking the cerebellum with this pathology by several other structures
involved: mainly the limbic system, thalamus, cerebral cortex, red nucleus, and reticular
formation. As a result, these anatomical and cellular changes in the cerebellum might trigger
the genesis and propagation of seizures.
Discussion:
We herewith outline the cerebellum's deep nuclei physiological pathways, responsible
for seizure spread via ion channels and neurotransmitter dysfunction. Additionally,
we describe the shifts in seizures produced after cell death, gene expression, and protein
interaction with their respective molecular and anatomical pathways.
Conclusion:
Finally, we highlight the role played by the cerebellum in seizure propagation
to the brain and how it can be counteracted in some subtypes of drug-resistant epilepsy.
Publisher
Bentham Science Publishers Ltd.
Subject
Pharmacology,Molecular Medicine,Drug Discovery,Biochemistry,Organic Chemistry
Cited by
1 articles.
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