Affiliation:
1. Department of Obstetrics, Maternal and Child Health Care Hospital of Wuxi, Affiliated Hospital of Jining
Medical University, Shandong, China
2. Institute for Fetology, First Hospital of Soochow University,
Jiangsu, China
Abstract
Abstract:
Melatonin, mainly released from the pineal gland, also produced in the reproductive
organs and cells, plays important roles in rhythms of the sleep-wake cycle, retardation
of ageing processes, and antioxidant/anti-inflammatory functions. As a key mediator
in reproductive systems, melatonin is participated in the reproductive process via regulating
gamete and embryo development and influences reproductive diseases and pregnancy
outcomes. The underlying mechanisms include epigenetic and other regulations,
which are interesting for exploring new targets in the prevention and treatment of reproductive
diseases. This review discusses the relationship between melatonin and reproductive
functions and dysfunction, as well as potential clinical applications of melatonin in
reproductive medicine. Notably, Developmental Origins of Health and Diseases (DOHaD)
is closely linked to reproduction, this article is the first to review the new progress
in studies on the possible relationship between melatonin and DOHaD.
Publisher
Bentham Science Publishers Ltd.
Subject
Pharmacology,Molecular Medicine,Drug Discovery,Biochemistry,Organic Chemistry
Cited by
4 articles.
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