Affiliation:
1. College of Pharmaceutical Science, Zhejiang University of Technology & Institute of Drug Development &
Chemical Biology, Zhejiang University of Technology, Hangzhou 310014, P. R. China
Abstract
Abstract:
Purine, one of the nucleotides, is an important substance for the metabolism
and regulation of the body. Purine plays a key role not only in the composition of coenzymes
but also in the supply of energy. Since purine was artificially synthesized, it has always
been an important scaffold for respiratory diseases, cardiovascular diseases, and anti-
tumor and anti-viral drugs. In addition to being widely used as competitive antagonists
in the treatment of diseases, purines can be used in combination with other drugs and as
precursors to benefit human life. Unfortunately, few new discoveries have been made in
recent years. In this article, purine drugs in the market have been classified according to
their different targets. In addition, their mechanism of action and structure-activity relationship
have also been introduced. This paper provides details of the signaling pathways
through which purine drugs can bind to the respective receptors on the surface of cells
and cause consequent reactions within the cell, which finally affect the targeted diseases.
The various receptors and biological reactions involved in the signaling for respective disease
targets within the cells are discussed in detail.
Publisher
Bentham Science Publishers Ltd.
Subject
Pharmacology,Molecular Medicine,Drug Discovery,Biochemistry,Organic Chemistry