Affiliation:
1. Laboratorio de Tecnologia dos Medicamentos, Federal University of Pernambuco (UFPE), Recife-PE, Brazil
2. Central de Analise de Farmacos, Medicamentos e Alimentos, Federal University of Vale do Sao Francisco (UNIVASF), Petrolina-PE, Brazil
Abstract
Background:
Inflammation is an essential response provided by the immune system,
ensuring the survival during microbial infection, tissue injury and other noxious conditions.
However, prolonged inflammatory processes are often associated with severe side effects
on health.
Objective:
This systematic review aimed to provide the evidence in the literature of the preclinical
and human anti-inflammatory activity of gallium compounds from 2000 to 2019 focused
on elucidating the mechanisms involved in the inflammatory process.
Methods:
Seven bibliographical databases were consulted (PubMed, Medline, ScienceDirect,
Scopus, Springer, Web of Science, and EBSCOhost). The selection of appropriate publications
and writing of this systematic review were based on the guidelines mentioned in the
PRISMA statement. Moreover, the assessment of the methodological quality of the selected
studies was also performed.
Results:
From a total of 3018 studies, 16 studies were included in this paper based on our eligibility
criteria, which showed promising and consistent results.
Conclusion:
Further research concerning specific inflammatory conditions is required.
Publisher
Bentham Science Publishers Ltd.
Subject
Pharmacology,Molecular Medicine,Drug Discovery,Biochemistry,Organic Chemistry
Cited by
17 articles.
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