Insights into the Effects of Dietary Omega-6/Omega-3 Polyunsaturated Fatty Acid (PUFA) Ratio on Oxidative Metabolic Pathways of Oncological Bone Disease and Global Health-Reference-Cited by-同舟云学术

Insights into the Effects of Dietary Omega-6/Omega-3 Polyunsaturated Fatty Acid (PUFA) Ratio on Oxidative Metabolic Pathways of Oncological Bone Disease and Global Health

Published:2021-04-20 Issue:9 Volume:28 Page:1672-1682
ISSN:0929-8673
Container-title:Current Medicinal Chemistry
language:en
Short-container-title:CMC

Author:

Bjørklund Geir¹^ORCID,Dadar Maryam²^ORCID,Doşa Monica Daniela³^ORCID,Chirumbolo Salvatore⁴^ORCID,Pen Joeri J.⁵^ORCID

Affiliation:

1. Council for Nutritional and Environmental Medicine (CONEM), Mo i Rana, Norway

2. Razi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization (AREEO), Karaj, Iran

3. Department of Pharmacology, Faculty of Medicine, Ovidius University, Constanta, Romania

4. Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy

5. Diabetes Clinic, Department of Internal Medicine, UZ Brussel, Vrije Universiteit Brussel (VUB), Brussels, Belgium

Abstract

Various nutrients have been designated as antioxidants, with a possible effect on diseases like cancer. This is partly due to their effect on prostaglandins, thereby affecting local pathological metabolic acidosis. This paper aims to summarize the culprit pathophysiological mechanisms involved, with a focus on the bone microenvironment. The omega- 6/omega-3 PUFA ratio is particularly investigated for its antioxidative effects, countering these pathways to fight the disease. This feature is looked at concerning its impact on health in general, with a particular focus on malignant bone metastasis.

Publisher

Bentham Science Publishers Ltd.

Subject

Pharmacology,Molecular Medicine,Drug Discovery,Biochemistry,Organic Chemistry

Cited by 6 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. The causal association of polyunsaturated fatty acids with allergic disease: A two-sample Mendelian randomization study;Frontiers in Nutrition;2022-09-09

2. Fatty Acid Profiles and Nutritional Evaluation of Fresh Sweet-Waxy Corn from Three Regions of China;Foods;2022-08-30

3. Genetically Predicted Circulating Omega-3 Fatty Acids Levels Are Causally Associated With Increased Risk for Systemic Lupus Erythematosus;Frontiers in Nutrition;2022-02-09

4. Reproductive toxicity and metabolic perturbations in male rats exposed to boron;Science of The Total Environment;2021-09

5. Enhanced lipid production by addition of malic acid in fermentation of recombinant Mucor circinelloides Mc-MT-2;Scientific Reports;2021-06-16