MicroRNAs in Atrial Fibrillation
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Published:2019-04-22
Issue:5
Volume:26
Page:855-863
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ISSN:0929-8673
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Container-title:Current Medicinal Chemistry
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language:en
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Short-container-title:CMC
Author:
Briasoulis Alexandros1, Sharma Shikha2, Telila Tesfaye1, Mallikethi-Reddy Sagar1, Papageorgiou Nikolaos3, Oikonomou Evangelos3, Tousoulis Dimitris3
Affiliation:
1. Wayne State University, Division of Cardiology, Detroit, Michigan, MI, United States 2. University of Michigan, Division of Cardiology, Arrhythmia services, Ann Arbor, Michigan, MI, United States 3. 1st Department of Cardiology, University of Athens Medical School, Athens, Greece
Abstract
MicroRNAs (miRNAs) are small non-coding RNAs, involved in regulation of
post-transcriptional gene expression. They exert key role not only in physiology and normal
development of the cardiovascular system but also in cardiovascular disease development
and progression. Recent animal and human studies of tissue specific miRNAs
have suggested a role in structural and electrical remodeling in atrial fibrillation (AF).
Their emerging role as biomarkers and potential therapeutic targets in patients with AF is
discussed in this review.
Publisher
Bentham Science Publishers Ltd.
Subject
Pharmacology,Molecular Medicine,Drug Discovery,Biochemistry,Organic Chemistry
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