Applications of Cellulose-based Materials in Sustained Drug Delivery Systems
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Published:2019-07-24
Issue:14
Volume:26
Page:2485-2501
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ISSN:0929-8673
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Container-title:Current Medicinal Chemistry
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language:en
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Short-container-title:CMC
Author:
Sun Bo1, Zhang Min1, Shen Jing2, He Zhibin2, Fatehi Pedram3, Ni Yonghao2
Affiliation:
1. Key Laboratory of Food Nutrition and Safety (Tianjin University of Science and Technology), Ministry of Education, Tianjin 300457, China 2. Department of Chemical Engineering, University of New Brunswick, Fredericton, New Brunswick, E3B 5A3, Canada 3. Department of Chemical Engineering, Lakehead University, 955 Oliver Road, Thunder Bay, Ontario P7B 5E1, Canada
Abstract
Bio-compatible, bio-degradable, and bio-available excipients are of critical interest
for drug delivery systems. Cellulose and its derivative-based excipients have been
well studied due to their green/natural and unique encapsulation/binding properties. They
are often used in controlled/sustained drug delivery systems. In these applications, cellulose
and its derivatives function generally can modify the solubility/gelling behavior of
drugs, resulting in different mechanisms for controlling the release profiles of drugs. In
this paper, the current knowledge in the structure and chemistry of conventional cellulose
derivatives, and their applications in drug delivery systems are briefly reviewed. The development
of innovative cellulose-based materials, including micro-cellulose (MC) and
nano-cellulose (NC) in the applications of sustained drug delivery, is also discussed.
Publisher
Bentham Science Publishers Ltd.
Subject
Pharmacology,Molecular Medicine,Drug Discovery,Biochemistry,Organic Chemistry
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