Affiliation:
1. Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China
Abstract
Intelligent polymeric nanogels, with the rationally designed stimuli-responsive
drug delivery and controlled drug release, have attracted considerable attention as an ideal
nanoplatform for activatable therapy. On the other hand, functional inorganic nanomaterials
are widely used as medical imaging agents due to their unique magnetic or optical
properties. The construction of stimuli-responsive polymeric nanogels incorporating with
functional inorganic nanomaterials inherits the excellent properties of both polymers and
inorganic nanomaterials, consequently, the resulted organic-inorganic hybrid nanogels
naturally exhibit stimuli-responsive multi-functionalities for both imaging and therapy. In
this review, we summarize the recent advances of stimuli-responsive organic-inorganic
hybrid nanogels. Firstly, we discuss the physical and chemical methods thus far developed
for the integration of polymeric nanogels and inorganic nanomaterials, and then we
show the typical examples of activatable theranostic applications using organic-inorganic
hybrid nanogels. In the end, the existing challenges and future directions are briefly discussed.
Funder
Natural Science Foundation of Zhejiang Province
National Key Research and Development Program of China
Fundamental Research Funds for the Central Universities
National Natural Science Foundation of China
Publisher
Bentham Science Publishers Ltd.
Subject
Pharmacology,Molecular Medicine,Drug Discovery,Biochemistry,Organic Chemistry
Cited by
15 articles.
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