Apoptosis and Anti-cancer Drug Discovery: The Power of Medicinal Fungi and Plants

Author:

Wong Jack Ho1,Sze Stephen Cho Wing2,Ng Tzi Bun1,Cheung Randy Chi Fai1,Tam Chit1,Zhang Kalin Yanbo2,Dan Xiuli1,Chan Yau Sang1,Shing Cho William Chi3,Ng Charlene Cheuk Wing4,Waye Mary Miu Yee1,Liang Weicheng1,Zhang Jinfang5,Yang Jie6,Ye Xiuyun6,Lin Juan6,Ye Xiujuan7,Wang Hexiang8,Liu Fang9,Chan David Wai10,Ngan Hextan Yuen Sheung10,Sha Ou11,Li Guohui12,Tse Ryan12,Tse Tak Fu12,Chan Helen12

Affiliation:

1. School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China

2. School of Chinese Medicine, LKS Faculty of Medicine, The University of Hong Kong, Sassoon Road, Hong Kong, China

3. Department of Clinical Oncology, Queen Elizabeth Hospital, Kowloon, Hong Kong, China

4. School of Medicine, King's College London, London, United Kingdom

5. Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, China

6. Fujian Key Laboratory of Marine Enzyme Engineering, Fuzhou University, Fuzhou 350116, Fujian, China

7. Key Laboratory of Biopesticide and Chemical Biology, Ministry of Education, and Key Laboratory of Plant Virology of Fujian Province, Institute of Plant Virology, Fujian Agriculture and Forestry University, Fuzhou, Fujian 350002, China

8. State Key Laboratory for Agrobiotechnology and Department of Microbiology, China Agricultural University, Beijing 100193, China

9. Department of Microbiology, College of Life Science, Nankai University, Tianjin 300071, China

10. Department of Obstetrics and Gynaecology, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam Road, Hong Kong, China

11. Department of Anatomy, Histology and Embryology, School of Basic Medical Sciences, Shenzhen University Health Science Center, Shenzhen, China

12. Vita Green Pharmaceuticals (HK) Ltd, Vita Green Health Products (HK) Ltd Genning Partners Company Limited, and Hong Kong Institute of Medical Research, Hong Kong, China

Abstract

The purpose of this account is to review the compounds capable of eliciting mitochondria-mediated apoptosis in cancer cells produced by medicinal fungi and plants. The medicinal fungi discussed encompass Cordyceps, Ganoderma species, Coriolus versicolor and Hypsizygus marmoreus. The medicinal plants discussed comprise Astragalus complanatus, Dendrobium spp, Dioscorea spp, Glycyrrhiza spp, Panax notoginseng, Panax ginseng, and Momordica charantia. These compounds have the potential of development into anticancer drugs.

Publisher

Bentham Science Publishers Ltd.

Subject

Pharmacology,Molecular Medicine,Drug Discovery,Biochemistry,Organic Chemistry

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