Affiliation:
1. Department of Psychiatry, University of Milan, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy
Abstract
Obsessive-Compulsive Disorder (OCD) is a highly disabling condition with early
onset and chronic course in most of the affected patients. In addition, OCD may show high
comorbidity and suicide attempt rates, which worsen the overall burden of the disease for patients
and their caregivers. First-line treatments for OCD consist of pro-serotonergic compounds
and cognitive-behavioral therapy. Nonetheless, many patients show only limited benefit
from such interventions and require additional “next-step” interventions, including augmentative
antipsychotics and glutamate-modulating agents. Based on the knowledge about
altered neurocircuitry in OCD, brain stimulation techniques, including transcranial magnetic
and electrical stimulations (TMS and tDCS) and deep brain stimulation (DBS), have been increasingly
investigated over the last decade, revealing positive results for otherwise intractable
and treatment-refractory patients. Available evidence in the field is in continuous evolution
and professionals actively involved in the management of OCD patients, psychiatrists in
particular, need to be updated about latest developments. Through the analysis of controlled
studies, meta-analyses, and International treatment guidelines, the present article is aimed at
providing the state of the art on the use of brain stimulation techniques for the treatment of
OCD.
Publisher
Bentham Science Publishers Ltd.
Subject
Pharmacology,Molecular Medicine,Drug Discovery,Biochemistry,Organic Chemistry
Cited by
8 articles.
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