Affiliation:
1. Departamento de Ciências Farmacêuticas, Centro de Ciências da Saúde, Universidade Federal de Pernambuco, 50740-520, Recife, PE, Brazil
Abstract
Background:
Leishmaniasis, a still important public health problem, exhibits environmental risk factors such as
massive migrations, urbanization, and deforestation. WHO research for Leishmaniasis has been mainly focused on the development
of new tools, such as diagnostic tests, drugs, and vaccines. During the drug development strategy, only a few
compounds seem promising and call for further study after the in vitro and in vivo preclinical tests.
Objective:
In this review, our group aimed to highlight the utmost research done during 2014 to 2019 in the fields of natural
and synthetic compounds, as well as repurposed drugs and new formulations tested in vivo for Leishmania spp.
Method:
Based on the literature search, we used the databases MEDLINE, PUBMED, CAPES PERIODIC and ELSEVIER
to delineate an interval of the last 5 years of research on each field.
Results:
Among the natural compounds tested, allicin and a fraction of potato tuber extract showed the most promising antileishmanial
activity. Concerning synthetic compounds, quinolines, bornyl ester, thymol, benzoxaborole and nitroimidazole
derivatives exhibited encouraging results. Moreover, repositioned alternatives involved combinations with known drugs and
monotherapy protocols as well. In these years, new formulations were widely assessed as drug delivery systems, such as nanoparticles,
micelles and liposomes in polymer conjugations.
Conclusion:
Drug repurposing and new formulations of already-known drugs are worthwhile approaches to promptly introduce
new treatment schemes to Leishmaniasis. Nevertheless, the interest in new synthetic compounds and new formulations
brings light to new treatment proposals and are notable lines of research.
Publisher
Bentham Science Publishers Ltd.
Subject
Pharmacology,Molecular Medicine,Drug Discovery,Biochemistry,Organic Chemistry
Cited by
2 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献