Targeting Protein Degradation in Cancer Treatment

Author:

Bjij Imane1,Hdoufane Ismail1,Soliman Mahmoud2,Najdoska-Bogdanov Menče3,Cherqaoui Driss1

Affiliation:

1. Universite Cadi Ayyad, Faculte des Sciences Semlalia, Departement de Chimie, Av. My Abdellah, BP2390 Marrakech, Morocco

2. Molecular Bio-Computation & Drug Design Lab, School of Health Sciences, University of KwaZulu-Natal, Westville, Durban 4000, South Africa

3. Institute of Chemistry, Faculty of Natural Sciences and Mathematics, Ss. Cyril and Methodius University, Skopje, North Macedonia

Abstract

The ubiquitin proteasome system (UPS) is a crucial protein degradation pathway that involves several enzymes to maintain cellular protein homeostasis. This system has emerged as a major drug target against certain types of cancer as a disruption at the cellular level of UPS enzyme components forces the transformation of normal cell into cancerous cell. Although enormous advancements have been achieved in the understanding of tumorigenesis, efficient cancer therapy remains a goal towards alleviating this serious health issue. Since UPS has become a promising target for anticancer therapies, herein, we provide comprehensive review of the ubiquitin proteasome system as a significant process for protein degradation. Herein, the anti-cancer therapeutic potential of this pathway is also discussed.

Publisher

Bentham Science Publishers Ltd.

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