Synthesis, Antioxidant and Anti-inflammatory Activities of 5-((styrylsulfonyl) methyl)-1,3,4-Oxadiazol / Thiadiazol-2-amine Derivatives-Reference-Cited by-同舟云学术

Synthesis, Antioxidant and Anti-inflammatory Activities of 5-((styrylsulfonyl) methyl)-1,3,4-Oxadiazol / Thiadiazol-2-amine Derivatives

Published:2019-10-23 Issue:11 Volume:16 Page:1233-1247
ISSN:1570-1808
Container-title:Letters in Drug Design & Discovery
language:en
Short-container-title:LDDD

Author:

Sravya Gundala¹,Nagarjuna Ummadi²,Padmavathi Venkatapuram²,Rajitha Galla³,priya Sakuri Chandi³,Padmaja Adivireddy²

Affiliation:

1. Chemical Engineering Institute, Ural Federal University,Yekaterinburg 620002, Russian Federation

2. Department of Chemistry, Sri Venkateswara University, Tirupati 517 502, Andhra Pradesh, India

3. Institute of Pharmaceutical Technology, Sri Padmavathi Mahila Visvavidyalayam (Women’s University), Tirupati 517 502, Andhra Pradesh, India

Abstract

Background: A new class of 5-(styrylsulfonylmethyl)-1,3,4-oxadiazol-2-amine and 5- (styrylsulfonylmethyl)-1,3,4-thiadiazol-2-amine derivatives were prepared by derivatization of amino function. Methods: All the synthesized compounds were tested for antioxidant and anti-inflammatory activities. Results: The 2-amino-3-chloro-N-(5-(4-methylstyrylsulfonylmethyl)-1,3,4-oxadiazol-2-yl)-propanamide (12b) and 3-chloro-N-(5-(4-methylstyrylsulfonylmethyl)-1,3,4-oxadiazol-2-yl)-butanamide (14b) displayed significant antioxidant activity, greater than the standard Ascorbic acid. Conclusion: Moreover, 12b and 14b also exhibited promising anti-inflammatory activity

Funder

University Grants Commission (UGC), New Delhi

Publisher

Bentham Science Publishers Ltd.

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

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