Affiliation:
1. Department of Chemistry, Faculty of Sciences, Ataturk University, 25240-Erzurum, Turkey
2. Department of Biotechnology, Faculty of Science, Bartin University, 74100-Bartin, Turkey
3. Department of Anesthesia, Regional Training and Research Hospital, 25240-Erzurum, Turkey
Abstract
Background:
The present paper focuses on the in vitro inhibition of some sedative drugs
such as Midazolam, Propofol, Hipnodex, Ketamine, and Pental sodium on acetylcholinesterase
(AChE), Butyrylcholinesterase (BChE), and α-glycosidase (α-Gly) enzymes.
Methods:
These drugs were tested in diverse concentrations, which showed positive effects in vitro
AChE, BChE, and α-Gly activities. Ki values were 20.14, 94.93, 636.78, 416.42, and 953.75 µM for
AChE, 17.52, 32.03, 88.02, 93.48, and 91.84 µM for BChE, and 10.87, 156.68, 48.21, 37.88,
151.01 µM for α-glycosidase, respectively.
Results:
An enhancing number of experiential observations show potentially harmful effects of
sedative drugs on the extension of brain.
Conclusion:
Midazolam exhibited effective inhibitory activity compared with the other drugs for
these enzymes.
Publisher
Bentham Science Publishers Ltd.
Subject
Drug Discovery,Pharmaceutical Science,Molecular Medicine
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