Affiliation:
1. Institute of Chemistry, University of Punjab, Lahore-54590, Pakistan
2. Department of Chemistry, University of Education, Lahore-54590, Pakistan
Abstract
Background:
Indazoleacetic acids and their pharmaceutically acceptable salts have been
claimed to be useful as anti-inflammatory, analgesic and antipyretic agents. They are active in the
treatment of respiratory diseases such as asthma, bronchitis, allergies and obstructive pulmonary
diseases.
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Objectives: We report herein a feasible study concerned about the design, synthesis, structure and in
vitro antimicrobial activity of 3-arylindazole-1-acetic acids derivatives. Series of compounds were
synthesized by alkylation of 3-arylindazoles.
Method:
Synthesized compounds were subjected to study the effect on microbial growth in vitro.
All synthesized compounds were found to exhibit antibacterial activities against a range of grampositive
(Bacillus subtilis, Staphylococcus aureus) and gram-negative bacteria (Shigella sonnei,
Escherichia coli) by broth dilution method.
Results:
The synthesized compounds exhibited antibacterial activities comparable to fluoroquinolones
and some compounds exhibited better activity. These findings suggest a great potential of
3-arylindazole-1-acetic acids as antibacterial compounds.
Conclusion:
3-Arylindazole-1-acetic acids are potent antimicrobial agent better than their respective
3-arylindazoles that revealed moderate activity against both gram positive and gram negative
bacteria.
Publisher
Bentham Science Publishers Ltd.
Subject
Drug Discovery,Pharmaceutical Science,Molecular Medicine
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