Synthesis of a Series of Chalcones and Related Flavones and Evaluation of their Antibacterial and Antifungal Activities
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Published:2018-11-01
Issue:1
Volume:16
Page:93-100
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ISSN:1570-1808
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Container-title:Letters in Drug Design & Discovery
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language:en
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Short-container-title:LDDD
Author:
Benouda Hind1, Bouchal Btissam2, Challioui Allal1, Oulmidi Abdelkader1, Harit Tarik1, Malek Fouad1, Riahi Abdelkhalek3, Bellaoui Mohammed2, Bouammali Boufelja1
Affiliation:
1. Laboratory of Organic Chemistry, Macromolecular and Natural Products, Faculty of Science, Mohammed First University, Oujda, Morocco 2. Genetics Unit, Faculty of Medicine and Pharmacy, Mohammed First University, Oujda, Morocco 3. Universite de Reims Champagne-Ardenne, Institut de Chimie Moleculaire de Reims (ICMR)-Groupe Methodologie en Synthese Organique, CNRS UMR 6229, Bât. Europol'Agro-Moulin de la Housse, BP 1039, 51687 Reims Cedex 2, France
Abstract
Background:
A series of chalcones and flavones were synthesized from
2’-hydroxyacetophenone and substituted aromatic aldehydes via Simmons-Schmidt condensation
followed by oxidative cyclization.
Methods:
Characterization of the obtained structures was established on the basis of their spectroscopic
data. The synthesized compounds were screened for their antimicrobial activities against five
bacterial strains (Citrobacter freundii, Staphylococcus aureus, Listeria monocytogenes, Salmonella
braenderup, Escherichia coli.) and two fungal strains (Candida albicans, Candida krusei).
Results:
The in vitro bioassay results indicated that some target compounds displayed moderate
(4d, 4e) to high (4a) antifungal activity against the pathogenic fungi C. albicans and C. krusei.
Conclusion:
For the antibacterial activity, only products 3d and 4d showed a weak antibacterial
activity. These compounds can lead to the design of new drugs with specific antifungal activity.
Publisher
Bentham Science Publishers Ltd.
Subject
Drug Discovery,Pharmaceutical Science,Molecular Medicine
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