Synthesis and Cytotoxicity Studies on Novel Piperazinylacetamides
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Published:2018-11-01
Issue:1
Volume:16
Page:45-51
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ISSN:1570-1808
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Container-title:Letters in Drug Design & Discovery
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language:en
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Short-container-title:LDDD
Author:
Bobtaina Eman1, Gurdal Enise Ece2, Durmaz Irem3, Atalay Rengul Cetin3, Yarim Mine2
Affiliation:
1. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Benghazi University, Belooan, Benghazi, Libya 2. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Yeditepe University, 34755, Kayisdagi, Istanbul, Turkey 3. Bioinformatics Department, Graduate School of Informatics, Middle East Technical University, Ankara, Turkey
Abstract
Background:
In this study, nine novel compounds, bearing N-[2-(4-substituted
piperazine-1-yl)acetyl]-N’-[bis-(4-fluorophenyl)methyl]piperazine structures were synthesized.
Methods:
Their cytotoxic properties were evaluated in vitro by NCI-60 Sulforhodamine B
(SRB) assay against human cancer cell lines: Huh7 (hepatocellular), MCF7 (breast) and HCT116
(colorectal).
Results and Conclusion:
According to the activity data, most of the compounds are more cytotoxic
than 5-fluorouracil against Huh7 and HCT116 cancer cell lines.
Publisher
Bentham Science Publishers Ltd.
Subject
Drug Discovery,Pharmaceutical Science,Molecular Medicine
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