Affiliation:
1. School of Pharmacy, Maharaja Agrasen University, Baddi, Solan, Himachal Pradesh, 174103, India
2. Maharishi
Arvind Institute of Pharmacy, Madhya Marg, Mansarovar, Jaipur, 302020, India
Abstract
Abstract:
The dosing pattern of the conventional drug delivery system results in continuously changing
and unpredictable plasma concentrations as this system has modest control on the release of the drug
along with almost negligible effectual concentration near the site of interest. The problems coupled with
conventional drug delivery can be triumphed over by employing osmotic drug delivery systems, which
are one of the most budding strategies utilizing osmotic pressure to release active pharmaceutical ingredients
in an optimized manner at a controlled rate. Various formulation parameters which influence the
release of drugs from these systems include osmotic pressure wielded by the core components, the drug’s
solubility, and the size of the delivery orifice in conjunction with the characteristics of the semipermeable
membrane. However, it is completely autonomous of the gastrointestinal tract’s anatomical environment
and concomitant meal ingestion. The aim of this manuscript is to study the earlier osmotic pumps, their
working principles, along with their limitations, and novel approaches having significant benefits over
older ones. The current manuscript covers all the aspects of the osmotic drug delivery system, including
its principle of osmosis, the historical background, its advantages and disadvantages, basic components,
various factors influencing its design, its various types, and evaluation parameters. Novel approaches to
osmotic drug delivery systems along with future prospective have also been described.
Publisher
Bentham Science Publishers Ltd.
Subject
Drug Discovery,Pharmaceutical Science,Molecular Medicine
Reference104 articles.
1. Sharma D.; Kumar D.; Singh M.; Singh G.; Rathore M.S.; A review on novel osmotically controlled drug delivery system. Indian J Pharm 2012,3(2),97-105
2. Gupta B.P.; Thakur N.; Jain N.P.; Banweer J.; Jain S.; Osmotically controlled drug delivery system with associated drugs. J Pharm Pharm Sci 2010,13(4),571-588
3. Prescott L.F.; The need for improved drug delivery in clinical practiceNovel Drug Delivery and Its Therapeutic Application 1989,1-11
4. Bhagat B.; Hapse S.; Darkunde S.; Osmotic drug delivery system: An overview. Int J Pharm Pharm Res 2014,2(1),29-44
5. Chen J.; Pan H.; Ye T.; Liu D.; Li Q.; Chen F.; Yang X.; Pan W.; Recent aspects of osmotic pump systems: Functionalization, clinical use and advanced imaging technology. Curr Drug Metab 2016,17(3),279-291