Affiliation:
1. College of Chemistry and Material Science, Shandong Agricultural University, Tai’an 271018, China
Abstract
Background:
Oxime compounds, including oxime ethers and oxime esters, possess
various biological activities. Many oxime ethers have been widely used in the fields of pesticides and
medicines. However, oxime ethers are rarely used in the field of pesticides.
Methods:
We chose the excellent fungicide pyrifenox as the lead compound, integrated pyridinyl,
adamantyl and benzoyl moieties into one molecule, while also designed and synthesized ten 1-
(adamantan-1-yl)ethanone oxime esters containing pyridinyl moiety. Moreover, we also evaluated
their preliminary antifungal activities against S. sclerotiorum and B. cinerea.
Results:
The target compounds were characterized by NMR, IR and HRMS. The preliminary bioactivity
test showed that they exhibited some antifungal activity to S. sclerotiorum and B. cinerea, and
EC50 values were in the range of 14.16-32.97 and 27.60-52.82 μg/mL, respectively.
Conclusion:
Some target compounds such as 3d, 3e, 3h and 3i, exhibited moderate activities against
S. sclerotiorum, with EC50 values of 14.16-18.18 μg/mL.
Funder
Natural Science Foundation of Shandong Province
Publisher
Bentham Science Publishers Ltd.
Subject
Drug Discovery,Pharmaceutical Science,Molecular Medicine
Cited by
4 articles.
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