Affiliation:
1. Cancer Institute, Fourth Hospital of Hebei Medical University, Shijiazhuang, China
Abstract
Aim:
To provide new methods and ideas for the clinical application of integrated traditional
Chinese and Western medicine in the treatment of esophageal cancer.
Background:
Traditional Chinese medicine compound Kushen injection (CKI) has been widely
used in the clinic with adjuvant radiotherapy and chemotherapy. However, the mechanism of action
of CKI as adjuvant therapy for esophageal cancer has not yet been described.
Method:
This study is based on network pharmacology, data mining, and molecular docking
technology to explore the mechanism of action of CKI in the treatment of esophageal cancer. We
obtained the effective ingredients and targets of CKI from the traditional Chinese medicine system
pharmacology database and analysis platform (TCMSP) and esophageal cancer-related genes from
the Online Mendelian Inheritance in Man (OMIM) and GeneCards databases.
Result:
CKI mainly contains 58 active components. Among them, the top 5 active ingredients are
quercetin, luteolin, naringenin, formononetin, and beta-sitostero. The target protein of the active
ingredient was matched with the genes associated with esophageal cancer. The active ingredients
targeted 187 esophageal cancer target proteins, including AKT1, MAPK1, MAPK3, TP53,
HSP90AA1, and other proteins. Then, we enriched and analyzed the Gene Ontology (GO) and
Kyoto Encyclopedia of Genes and Genomes (KEGG) and used AutoDockVina to dock the core
targets and compounds. Finally, PyMOL and Ligplot were used for data visualization.
Conclusion:
This study provides a new method and ideas for the clinical application of integrated
traditional Chinese and Western medicine in the treatment of esophageal cancer.
Funder
National Natural Scientific Foundation of China
Publisher
Bentham Science Publishers Ltd.
Subject
Drug Discovery,Molecular Medicine,General Medicine
Cited by
2 articles.
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