2D QSAR Analysis of Substituted Quinoxalines for their Antitubercular and Antileptospiral Activities

Author:

Natarajan Ramalakshmi1,Puratchikody Ayarivan2,Muralidharan Vignesh3,Doble Mukesh3,Subramani Arunkumar4

Affiliation:

1. Department of Pharmaceutical Chemistry, C.L. Baid Metha College of Pharmacy, Chennai 600 097, India

2. Department of Pharmaceutical Technology, Anna University Tiruchirappalli, Tiruchirappalli 620 024, India

3. Department of Biotechnology, Indian Institute of Technology Madras, Chennai 600036, India

4. Department of Pharmaceutical Sciences, College of Pharmacy, Gulf Medical University, 4184, Ajman, United Arab Emirates

Abstract

Background: The Quantitative structure activity relationship for thirty two novel substituted quinoxalines was performed for their antitubercular (Mycobacterium tuberculosis H37Rv) and antileptospiral (Leptospirainterrogans) activities. The quinoxalines were substituted with azetidinones, thiazolidinones and fluoroquinolones. Several compounds exhibited good activity against both the infections and they all possess fluoroquinolone moiety with the quinoxaline. Methods: The models developed showed good linear relationship (r2 = 0.71-0.88), with an internal predictive ability (q2> 0.61) and good external predictive ability (pred_r2>0.71). The compounds were separated into a training set on which regression was performed and a test set on which the predictive ability of the model was tested. Other statistical parameters including Ro2, Ro’2, k, k’ and Z- score were in the acceptable range. Results and Conclusion: The descriptors obtained explained the necessity of spatial orientation of atoms including branching and adjacency, presence of electronegative groups, balance between lipophilic elements and their binding strengths.

Publisher

Bentham Science Publishers Ltd.

Subject

Drug Discovery,Molecular Medicine,General Medicine

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