Affiliation:
1. Department of Pharmacology, Dr. D.Y. Patil Institute of Pharmaceutical Sciences and Research, Pune,India
2. Dr. D.Y. Patil Vidyapeeth, Pune,India
3. Department of Pharmaceutical Chemistry, Dr. D.Y. Patil Institute of Pharmaceutical Sciences and Research, Pune,India
Abstract
Diabetes is a chronic metabolic disorder of the endocrine system characterized by an increase
in blood glucose level. Several factors, such as pancreatic damage, oxidative stress, infection, genetic
factor, obesity, liver dysfunction, play a vital role in the pathogenesis of diabetes, which further leads to
serious diabetic complications. The diabetic wound is one such complication where the wound formation
occurs, especially due to pressure and its healing process is disrupted due to factors, such as hyperglycemia,
neuropathy, nephropathy, peripheral vascular disease, reduction of blood flow, atherosclerosis,
impaired fibroblast. The process of wound healing is delayed due to different abnormalities like alteration
in nitric oxide level, increase in aldose reductase, sorbitol, and fructose. Therefore, diabetic
wound requires more time to heal as compared to the normal wound. Healing time is delayed in diabetic
wound due to many factors, such as stress, decreased oxygenation supply, infection, decreased blood
flow, impaired proliferation and migration rate, impaired growth factor production, impaired keratinocytes
proliferation and migration, and altered vascular endothelial mediators. The current treatment for
diabetic wounds includes wound patches, oxygenation therapy, hydrogel patches, gene therapy, laser
therapy, and stem cell therapy. Medications with phytoconstituents are also one way to manage the diabetic
wound, but it is not more effective for quick healing. The objective of this review is to understand
the potential of various management options which are available for diabetic wound, with a special focus
on biological cells.
Publisher
Bentham Science Publishers Ltd.
Subject
Endocrinology,Endocrinology, Diabetes and Metabolism