Affiliation:
1. Endeavour College of Natural Health, Perth, Western, Australia
2. School of Pharmacy and Biomedical Sciences, Curtin University, East Perth, Western, Australia
Abstract
Alpha-lipoic acid (ALA) is a substantial antioxidant in the prevention of diabetes and diabetes
complications. It can regenerate other antioxidants like vitamin E, vitamin C, Coenzyme
Q10 and glutathione and is often known as a universal antioxidant. Antioxidants play a role in diabetes
treatment due to hyperglycemia-induced stimulation of the polyol pathway and formation of
advanced glycation end products (AGE) and reactive oxygen species (ROS). Clinical trials examining
alpha-lipoic acid supplementation on diabetic neuropathy, nephropathy, cardiomyopathy and
erectile dysfunction display positive results, particularly in pain amelioration in neuropathy, asymmetric
dimethylarginine reductions in nephropathy and improved oscillatory potential and contrast
sensitivity in retinopathy. In diabetic cardiomyopathy (DCM), ALA offers protection through inhibition
of NF-kB activation, reduction of fas-ligand and decrease in matrix metalloproteinase-2.
This comprehensive review summarises and provides an understanding of the importance of alpha-
lipoic acid supplementation to prevent diabetes complications.
Publisher
Bentham Science Publishers Ltd.
Subject
Endocrinology,Endocrinology, Diabetes and Metabolism
Cited by
22 articles.
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