Metformin in type 2 diabetes: Evidence for its beneficial effects on frailty and sarcopenia

Author:

Papanas Nikolaos1ORCID,Pyrgioti Elisavet E.2ORCID,Karakousis Nikolaos D.1ORCID,Georgakopoulos Petros N.3

Affiliation:

1. Second Department of Internal Medicine, Diabetes Centre-Diabetic Foot Clinic, Democritus University of Thrace, Alexandroupolis, Greece

2. Private Practice, Athens, Greece

3. Primary Healthcare, Internal Medicine Department, Amarousion, Attica, Greece

Abstract

Abstract: This narrative review aimed to discuss the potential interplay among frailty syndrome, sarcopenia and metformin in type 2 diabetes mellitus (T2DM). There is emerging evidence on the potential protective role of metformin on both frailty and sarcopenia. However, results are not always consistent. Thus, further research is needed to provide a definitive answer on any role of metformin in improving frailty and/or sarcopenia in T2DM.

Publisher

Bentham Science Publishers Ltd.

Subject

Endocrinology,Endocrinology, Diabetes and Metabolism

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