Advancement in Understanding the Concept of Epithelial to Mesenchymal
Transition in Pancreatic β-Cells: Implication in Diabetes
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Published:2023-07
Issue:6
Volume:19
Page:
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ISSN:1573-3998
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Container-title:Current Diabetes Reviews
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language:en
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Short-container-title:CDR
Author:
Kumar Anujith1,
Francis Meenal1,
Ashok Akshaya1,
Ashwathnarayan Ashwini1,
Banerjee Shreetama1,
Prasanna Jyothi1
Affiliation:
1. Manipal Institute of Regenerative Medicine, Manipal Academy of Higher Education, Manipal, India
Abstract
Abstract:
Distinct molecular processes are engaged during histogenesis, and Epithelial to Mesenchymal
Transition (EMT) is one of the key evolutionarily conserved processes that facilitates organ
development. Molecular pathways governing EMT are embedded within developmental programs
and operate in cells of different tissues. Among varied cell types, EMT in pancreatic β-cells is of
greater interest as the existence of EMT in these cells is highly debated. Although in vitro generation
of human islet-derived mesenchymal progenitor cells has been proven beyond doubt, the existence
of EMT in pancreatic β-cells in vivo remains enigmatic. Understanding the in-depth process of
EMT in in vivo human β-cells is challenged by the limitations of lineage-tracing studies, which are
otherwise feasible in mice. Exploring EMT of β-cells would greatly facilitate the generation of clinically
relevant β-cells either by enhancing long-term in vitro culture of endogenous islets or by differentiation
of pluripotent stem cells to mature β-cells. This review is an update on the recent progress
in understanding the EMT process of β-cells and how the investigations have helped to resolve
the mystery of the existence of EMT in pancreatic β-cells.
Publisher
Bentham Science Publishers Ltd.
Subject
Endocrinology,Endocrinology, Diabetes and Metabolism
Cited by
2 articles.
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