Latent Mastocytosis Triggered by COVID-19 Vaccination: A Case Report

Author:

Calogiuri Gianfranco1,Foti Caterina2,Congedo Maurizio3,Nettis Eustachio4,Paladini Luigi15,Greco Giuseppina6,Pavone Vincenzo6,Vacca Angelo7

Affiliation:

1. Pneumology and Respiratory Diseases Department, Civil Hospital Vito Fazzi Lecce, Italy

2. Section of Dermatology, Department of Biomedical Science and Human Oncology, Bari University “Aldo Moro”, Piazza Giulio Cesare, Bari, Italy

3. Dermatology Service, Civil Hospital Vito Fazzi, Lecce, Italy

4. Department of Emergency and Organ Transplantation, School of Allergology and Clinical Immunology, Bari University “Aldo Moro” Bari, Italy

5. Department of Medical and Surgical Sciences, 'Institute of Respiratory Diseases', University Hospital, Foggia, Italy

6. Hematology Department, Cardinale Panico Hospital, Tricase Lecce, Italy

7. Department of Biomedical Sciences and Human Oncology, University of Bari 'Aldo Moro', Medical School, Bari, Italy

Abstract

Background: Hereby, we describe the first case of latent mastocytosis triggered by mRNA-based vaccine to prevent COVID-19 infection. Case Presentation: In a 42-year-old Arabian man affected by slight, undiagnosed mastocytosis, the second dose of the COVID-19 vaccine made more blatant his latent disease. The postvaccination diagnostic iter is illustrated and the potential reasons causing the onset of the cutaneous mastocytosis are discussed. Conclusion: Clinicians should keep a longer follow-up of their patients after the COVID-19 vaccination, not related to few hours, for the risk of immediate-type adverse events only.

Publisher

Bentham Science Publishers Ltd.

Subject

Immunology and Allergy,Endocrinology, Diabetes and Metabolism

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