Pregnancy in Autoimmune Hypophysitis: Management of a Rare Condition

Author:

Costanza Flavia12,Cicia Martina12,Giampietro Antonella12,Tartaglione Tommaso3,Angelini Flavia1,Zoli Angelo4,Ferrazzani Sergio5,De Marinis Laura12,Pontecorvi Alfredo12,Bianchi Antonio12,Chiloiro Sabrina12

Affiliation:

1. Department of Translational Medicine and Surgery, Catholic University of the Sacred Heart, Rome, Italy

2. Department of Endocrinology, Diabetology and Internal Medicine, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy

3. Department of Imaging, Radiation Therapy and Hematology, Catholic University of the Sacred Heart, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy

4. Division of Rheumatology, Catholic University of the Sacred Heart, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy

5. Department of Obstetrics and Gynecology, Catholic University of Sacred Hearth, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy

Abstract

Introduction: Hypophysitis is an inflammatory disorder of the pituitary gland. It can manifest variously, with endocrinological and neuro-ophthalmologic symptoms and signs, due to the compression of sellar and parasellar structures. Case Representation: Although hypophysitis is rare, this pituitary disease can occur during pregnancy or in the postpartum period. In this report, we describe the case of a woman with partial hypopituitarism secondary to autoimmune hypophysitis who, five years after the diagnosis and the immunosuppressive treatment, had an uneventful pregnancy and successfully delivered a healthy infant at term. Conclusion: We reported the clinical history of the patient and the evolution of the disease and also reviewed the management and treatment of autoimmune hypophysitis during pregnancy.

Publisher

Bentham Science Publishers Ltd.

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