Sustainable Synthesis of Guanidine Derivatives and Computational Assessment of their Antidiabetic Efficacy-Reference-Cited by-同舟云学术

Sustainable Synthesis of Guanidine Derivatives and Computational Assessment of their Antidiabetic Efficacy

Published:2024-07-02 Issue: Volume:24 Page:
ISSN:1871-5303
Container-title:Endocrine, Metabolic & Immune Disorders - Drug Targets
language:en
Short-container-title:EMIDDT

Author:

Imkongyanger ¹,Richa Kikoleho²,Lotha Tsenbeni N.¹,Ao Ketiyala³,Rudithongru Lemzila³,Nakro Vevosa³,Ritse Vimha³,Namsa Nima D.⁴,Pankaj Pranay Punj⁵,Sinha Upasana Bora⁶,Jamir Latonglila³^ORCID

Affiliation:

1. Sustainable Synthesis of Guanidine Derivatives and Computational Assessment of their Antidiabetic Efficacy

2. Department of Biotechnology, St. Joseph University, Chumoukedima, 797115, Nagaland, India

3. Department of Environmental Science, Nagaland University, Lumami, 798627, Nagaland, India

4. Department of Molecular Biology and Biotechnology, Tezpur University, Napaam, 784028, Assam, India

5. Department of Zoology, Nagaland University, Lumami, 798627, Nagaland, India

6. Department of Chemistry, Nagaland University, Lumami, 798627, Nagaland, India

Abstract

Background:: Type 2 Diabetes Mellitus (T2DM) represents a significant and pressing worldwide health concern, necessitating the quest for enhanced antidiabetic pharmaceuticals. Guanidine derivatives, notably metformin and buformin, have emerged as pivotal therapeutic agents for T2DM management. Aims: The present study introduces an efficient one-pot synthesis method for the production of symmetrical guanidine compounds. Methods:: This synthesis involves the reaction of isothiocyanates with secondary amines, employing an environmentally friendly and recyclable reagent, tetrabutylphosphonium tribromide (TBPTB). Results:: A comprehensive assessment of the biological activity of the synthesized guanidine compounds, specifically in the context of T2DM, has been rigorously conducted. Conclusion:: Additionally, computational analyses have unveiled their substantial potential as promising antidiabetic agents. Results highlight the relevance of these compounds in the ongoing pursuit of novel therapeutic solutions for T2DM.

Publisher

Bentham Science Publishers Ltd.