Affiliation:
1. Noida Institute of Engineering and Technology Biotechnology Greater Noida India
2. Chandigarh University Research Centre Chandigarh India
Abstract
Abstract::
Lung cancer and tuberculosis (TB) are classified as the second-most life-threatening
diseases globally. They both are exclusively represented as major public health risks and might
exhibit similar symptoms, occasionally diagnosed simultaneously. Several epidemiological
studies suggest that TB is a significant risk factor for the progression of lung cancer. The staggering
mortality rates of pulmonary disorders are intrinsically connected to lung cancer and TB.
Numerous factors play a pivotal role in the development of TB and may promote lung carcinogenesis,
particularly among the geriatric population. Understanding the intricacies involved in
the association between lung carcinogenesis and TB has become a crucial demand of current
research. Consequently, this study aims to comprehensively review current knowledge on the
relationship between tuberculosis-related inflammation and the emergence of lung carcinoma,
highlighting the impact of persistent inflammation on lung tissue, immune modulation, fibrosis,
aspects of reactive oxygen species, and an altered microenvironment that are linked to the progression
of tuberculosis and subsequently trigger lung carcinoma.
Publisher
Bentham Science Publishers Ltd.