Affiliation:
1. Department of Technology of Drug Form, Faculty of Pharmacy, Medical University of Lodz, Muszynskiego 1, 90-151 Lodz, Poland
2. Department of Applied Pharmacy, Faculty of Pharmacy, Medical University of Lodz, Muszynskiego 1, 90-151 Lodz, Poland
Abstract
About 40% of newly-discovered entities are poorly soluble in water, and this may be an obstacle
in the creation of new drugs. To address this problem, the present review article examines the
structure and properties of cyclodextrins and the formation and potential uses of drug – cyclodextrin
inclusion complexes. Cyclodextrins are cyclic oligosaccharides containing six or more D-(+)-
glucopyranose units linked by α-1,4-glycosidic bonds, which are characterized by a favourable toxicological
profile, low local toxicity and low mucous and eye irritability; they are virtually non-toxic
when administered orally. They can be incorporated in the formulation of new drugs in their natural
form (α-, β-, γ-cyclodextrin) or as chemically-modified derivatives. They may also be used as an excipient
in drugs delivered by oral, ocular, dermal, nasal and rectal routes, as described in the present
paper. Cyclodextrins are promising compounds with many beneficial properties, and their use may be
increasingly profitable for pharmaceutical scientists.
Funder
Medical University of Lodz
Publisher
Bentham Science Publishers Ltd.
Subject
Clinical Biochemistry,Drug Discovery,Pharmacology,Molecular Medicine
Cited by
25 articles.
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