Affiliation:
1. College of Marine Science, Shandong University, Weihai 264209, China
Abstract
Epigenetic modifications ensure the maintenance of normal cellular functions, and their
dysregulation is frequently found in many disease states, including cancer. Nowadays, the most studied
epigenetic dysregulation associated with tumorigenesis, cancer progression and metastasis refers to
the variations in DNA methylation, histone modification and chromatin structure. The development of
novel agents targeting these processes has enabled us to open up new pathways for anti-cancer strategies.
To date, many small molecules have been designed to target epigenetic modifiers, and some of
them are currently in clinical trials for patients with haematologic malignancies and solid tumours.
With this in mind, we elaborate on basic information on epigenetic modifications and potential epigenetic
therapies for cancer treatment.
Funder
Fundamental Research Funds for the Central Universities
National Natural Science Foundation of China
Publisher
Bentham Science Publishers Ltd.
Subject
Clinical Biochemistry,Drug Discovery,Pharmacology,Molecular Medicine
Cited by
3 articles.
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