Affiliation:
1. Neuroscience Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
2. Medical Toxicology Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Abstract
Nowadays, natural compounds of plant origin with anticancer effects have gained more attention
because of their clinical safety and broad efficacy profiles. Autophagy is a multistep lysosomal
degradation pathway that may have a unique potential for clinical benefit in the setting of cancer
treatment. To retrieve articles related to the study, the databases of Google Scholar, Web of sciences,
Medline and Scopus, using the following keywords: Autophagic pathways; herbal medicine, oncogenic
autophagic pathways, tumor-suppressive autophagic pathways, and cancer were searched. Although
natural plant compounds such as resveratrol, curcumin, oridonin, gossypol, and paclitaxel have proven
anticancer potential via autophagic signaling pathways, there is still a great need to find new natural
compounds and investigate the underlying mechanisms, to facilitate their clinical use as potential anticancer
agents through autophagic induction.
Publisher
Bentham Science Publishers Ltd.
Subject
Clinical Biochemistry,Drug Discovery,Pharmacology,Molecular Medicine
Cited by
3 articles.
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