Potential Applications of Induced Pluripotent Stem Cells for Cardiovascular Diseases
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Published:2019-05-09
Issue:7
Volume:20
Page:763-774
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ISSN:1389-4501
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Container-title:Current Drug Targets
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language:en
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Short-container-title:CDT
Author:
Wang Xiaotong1, Han Zhenbo1, Yu Ying1, Xu Zihang1, Cai Benzhi1, Yuan Ye1
Affiliation:
1. Department of Pharmacy, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China
Abstract
Owning the high incidence and disability rate in the past decades, to be expected, cardiovascular
diseases (CVDs) have become one of the leading death causes worldwide. Currently, induced
pluripotent stem cells (iPSCs), with the potential to form fresh myocardium and improve the functions
of damaged hearts, have been studied widely in experimental CVD therapy. Moreover, iPSC-derived
cardiomyocytes (CMs), as novel disease models, play a significant role in drug screening, drug safety
assessment, along with the exploration of pathological mechanisms of diseases. Furthermore, a lot of
studies have been carried out to clarify the biological basis of iPSCs and its derived cells in the treatment
of CVDs. Their molecular mechanisms were associated with release of paracrine factors, regulation
of miRNAs, mechanical support of new tissues, activation of specific pathways and specific enzymes,
etc. In addition, a few small chemical molecules and suitable biological scaffolds play positive
roles in enhancing the efficiency of iPSC transplantation. This article reviews the development and
limitations of iPSCs in CVD therapy, and summarizes the latest research achievements regarding the
application of iPSCs in CVDs.
Publisher
Bentham Science Publishers Ltd.
Subject
Clinical Biochemistry,Drug Discovery,Pharmacology,Molecular Medicine
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